Mirica™ - Palmitoylethanolamide (PEA) and Luteolin 60 caps

Mirica™ - Palmitoylethanolamide (PEA) and Luteolin 60 caps

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What is PEA?

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide. It is widely distributed throughout the body's tissues and is synthesized on demand. It was first isolated in 1957 as a component in egg yolks. It has been studied for its remarkable effects on the body's inflammatory response since 1975. (Hesselink 2017)

Mirica contains OptiPEA®, which is made by a pharmaceutical manufacturer in The Netherlands. OptiPEA® is 99.6% - 100% pure. 

 

The Research

In a recent meta-analysis of PEA involving a total of 1484 chronic pain patients, those taking PEA reported pain levels an average of 2.7 points lower than the control groups after 60 days.* (Paladini 2016)

 

How does PEA work?

PEA regulates many physiological responses associated with pain and inflammation.* This is achieved partially by activation the PPAR-alpha receptor. Activation of this nuclear receptor aids in the restoration of metabolic balance within cells and plays an important role in analgesia.*

Additional targets of PEA are mast cells and glial cells.* Excessive activation of these satellite, non-neuronal cells has been shown to maintain chronic pain. PEA inhibits excessive activity of these cells and restores their normal activity.* PEA also reduces the activity of the pro-inflammatory enzyme COX.*  It acts indirectly on CB2 receptors as well. In addition to these, other mechanisms of action have been identified.*  (Gabrielsson 2016)  (Hesselink 2017)

 

Is PEA safe?

PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses.

 

What is Luteolin?

Luteolin is a potent bioflavonoid with antioxidant and anti-inflammatory properties.* Like PEA, luteolin has several mechanisms of action. It is a potent modulator of microglial activation and inhibitor of pro-inflammatory cytokine production.* (Dirscherl 2010)  It also acts on GABA and opioid receptors in the spinal cord.* (Li 2015) 

 

Is Luteolin safe?

The recommended daily dose of Mirica is equlivant to the amount of luteolin found in one artichoke. At this dose luteolin is safe and no side effects have been reported. 




Calm and protect the nervous system and support a healthy inflammatory response with the synergistic action of palmitoylethanolamide (PEA) and luteolin.*


Made with OptiPEA® (patent pending) from the Netherlands

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